MMPs play a role in the controlled degradation of the extracellular matrix. Although the anti‐inflammatory mechanism of nanocrystalline silver is not clear (13), it might reduce inflammation by fighting the bacterial infection (18)– an important reason for persistent inflammation which leads to infiltration of neutrophils and elevated matrix metalloproteinases (MMPs) in infected wounds. (17) showed the safety and efficacy of a nanocrystalline silver‐coated polyethylene mesh in preventing infection in burn wounds by reducing the bacterial burden. However, different methods have been used to impregnate wound dressings with silver compound, but coating a textile, fibre or polymer mesh with a layer of nanocrystalline silver resulted in sustained release and long‐acting antibacterial wound dressings 9, 16. Metallic and ionic silver was used in a variety of medicinal and medical devices such as topical creams, emulations, catheters and medical prostheses 10, 11, 12, 13, 14, 15. One of the silver products that is increasingly being used to cover burn wounds, traumatic injuries, skin graft, diabetic ulcers, incisions, abrasions and minor cuts are silver dressings (9). Silver recently gained renewed attention in the treatment of bacterial infection and prevention of wound sepsis in different prescription forms in conjunction with other materials such as wound dressings impregnated with silver salts or metal nanoparticles 6, 7, 8. Silver has been known to have bactericidal properties and it has been at the core of many studies for several years (5). Silver sulfadiazine (AgSD) is one of the conventional therapeutics that has been used for a long time (3), but there are some reported adverse effects that increase the demand for new therapies and technologies in burn wound management (4). Burn wounds have a higher chance of bacterial infection because of the accumulation of dead tissues, compromised immune system and blood supply, and infection is one of the major reasons of death after burn injuries (2). Burn wounds need to be healed and reepithelialised as soon as possible in order to prevent infection, functional reduction, dysfunctions and cosmetic after‐effects (1).
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